A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres

Citation:
Chu, JF, Wang ZF, Tseng TY, Chang TC.  2011.  A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres, Jun. Journal of the Chinese Chemical Society. 58:296-300., Number 3

Abstract:

We present a simple method based on the Cu(2+) induced unfolding of G-quadruplex (G4) of human telomere sequence d[AG(3)(T(2)AG(3))(3)] to screen a number of 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC) analogues for better G4 stabilizers. Using circular dichroism (CD), the screening results suggest that the tri-cations of 9-substituted BMVC derivatives are better G4 stabilizers than the bi-cations of BMVC. In addition, 3,6-bis(1-methyl-4-vinylpyrazinium)carbazole diiodide (BMVC4) is likely a better core molecule than BM VC for G4 stabilizers.

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