<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chu, J. F.</style></author><author><style face="normal" font="default" size="100%">Wang, Z. F.</style></author><author><style face="normal" font="default" size="100%">Tseng, T. Y.</style></author><author><style face="normal" font="default" size="100%">Chang, T. C.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of the Chinese Chemical Society</style></secondary-title><alt-title><style face="normal" font="default" size="100%">J Chin Chem Soc-Taip</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bmvc derivatives</style></keyword><keyword><style  face="normal" font="default" size="100%">cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">cells</style></keyword><keyword><style  face="normal" font="default" size="100%">conformational switch</style></keyword><keyword><style  face="normal" font="default" size="100%">copper induced unfolding</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Design</style></keyword><keyword><style  face="normal" font="default" size="100%">g-quadruplex</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">molecule</style></keyword><keyword><style  face="normal" font="default" size="100%">stabilizer</style></keyword><keyword><style  face="normal" font="default" size="100%">target</style></keyword><keyword><style  face="normal" font="default" size="100%">terminal transferase</style></keyword><keyword><style  face="normal" font="default" size="100%">yeast telomere</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jun</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000293668100005</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">58</style></volume><pages><style face="normal" font="default" size="100%">296-300</style></pages><isbn><style face="normal" font="default" size="100%">0009-4536</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We present a simple method based on the Cu(2+) induced unfolding of G-quadruplex (G4) of human telomere sequence d[AG(3)(T(2)AG(3))(3)] to screen a number of 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC) analogues for better G4 stabilizers. Using circular dichroism (CD), the screening results suggest that the tri-cations of 9-substituted BMVC derivatives are better G4 stabilizers than the bi-cations of BMVC. In addition, 3,6-bis(1-methyl-4-vinylpyrazinium)carbazole diiodide (BMVC4) is likely a better core molecule than BM VC for G4 stabilizers.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000293668100005</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;804QCTimes Cited:0Cited References Count:37&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Chang, TCAcad Sinica, Inst Atom &amp; Mol Sci, Taipei, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, Taipei, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, Taipei, TaiwanNatl Taiwan Normal Univ, Dept Chem, Taipei, TaiwanNatl Taiwan Univ, Dept Chem, Taipei 10764, TaiwanNatl Yang Ming Univ, Inst Biophoton, Taipei 112, Taiwan</style></auth-address></record></records></xml>