@article {577,
	title = {A Novel Method for Screening G-quadruplex Stabilizers to Human Telomeres},
	journal = {Journal of the Chinese Chemical Society},
	volume = {58},
	number = {3},
	year = {2011},
	note = {<p>804QCTimes Cited:0Cited References Count:37</p>
},
	month = {Jun},
	pages = {296-300},
	abstract = {<p>We present a simple method based on the Cu(2+) induced unfolding of G-quadruplex (G4) of human telomere sequence d[AG(3)(T(2)AG(3))(3)] to screen a number of 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide (BMVC) analogues for better G4 stabilizers. Using circular dichroism (CD), the screening results suggest that the tri-cations of 9-substituted BMVC derivatives are better G4 stabilizers than the bi-cations of BMVC. In addition, 3,6-bis(1-methyl-4-vinylpyrazinium)carbazole diiodide (BMVC4) is likely a better core molecule than BM VC for G4 stabilizers.</p>
},
	keywords = {bmvc derivatives, cancer, cells, conformational switch, copper induced unfolding, DNA, Drug Design, g-quadruplex, inhibition, molecule, stabilizer, target, terminal transferase, yeast telomere},
	isbn = {0009-4536},
	url = {<Go to ISI>://WOS:000293668100005},
	author = {Chu, J. F. and Wang, Z. F. and Tseng, T. Y. and Chang, T. C.}
}
