<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chang, C. C.</style></author><author><style face="normal" font="default" size="100%">Chu, J. F.</style></author><author><style face="normal" font="default" size="100%">Kao, F. J.</style></author><author><style face="normal" font="default" size="100%">Chiu, Y. C.</style></author><author><style face="normal" font="default" size="100%">Lou, P. J.</style></author><author><style face="normal" font="default" size="100%">Chen, H. C.</style></author><author><style face="normal" font="default" size="100%">Chang, T. C.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Verification of antiparallel G-quadruplex structure in human telomeres by using two-photon excitation fluorescence lifetime imaging microscopy of the 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide molecule</style></title><secondary-title><style face="normal" font="default" size="100%">Analytical Chemistry</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Anal Chem</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">c-myc promoter</style></keyword><keyword><style  face="normal" font="default" size="100%">carbazole</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug Design</style></keyword><keyword><style  face="normal" font="default" size="100%">DYNAMICS</style></keyword><keyword><style  face="normal" font="default" size="100%">region</style></keyword><keyword><style  face="normal" font="default" size="100%">target</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr 15</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">&lt;Go to ISI&gt;://WOS:000236948300046</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">78</style></volume><pages><style face="normal" font="default" size="100%">2810-2815</style></pages><isbn><style face="normal" font="default" size="100%">0003-2700</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Different G-quadruplex structures for the human telomeric sequence d(T(2)AG(3))(4) in vitro have been documented in the presence of sodium and potassium. Verification of the G-quadruplex structures in human telomeres in vivo is the main issue in establishing the biological function of the G-quadruplex structures in telomeres as well as the development of anticancer agents. Here we have applied two-photon excitation fluorescence lifetime imaging microscopy to measure the fluorescence lifetime of the BMVC molecule upon interaction with various DNA structures. The distinction in lifetime measured with submicrometer spatial resolution in two-photon excitation fluorescence lifetime imaging microscopy provides a powerful approach not only to verify the existence of the antiparallel G-quadruplex structure in human telomeres but also to map its localizations in metaphase chromosomes.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000236948300046</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;034RMTimes Cited:48Cited References Count:26&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Chang, TCAcad Sinica, Inst Atom &amp; Mol Sci, POB 23-166, Taipei 106, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, POB 23-166, Taipei 106, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, Taipei 106, TaiwanNatl Taiwan Normal Univ, Dept Chem, Taipei, TaiwanNatl Yang Ming Univ, Inst Biophoton Engn, Taipei 11221, TaiwanNatl Sun Yat Sen Univ, Inst Electroopt Engn, Kaohsiung 80424, TaiwanNatl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan</style></auth-address></record></records></xml>