<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wang, Z. F.</style></author><author><style face="normal" font="default" size="100%">Chang, T. C.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol</style></title><secondary-title><style face="normal" font="default" size="100%">Nucleic Acids Res</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nucleic acids research</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">*G-Quadruplexes</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbazoles/*chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Circular Dichroism</style></keyword><keyword><style  face="normal" font="default" size="100%">Ligands</style></keyword><keyword><style  face="normal" font="default" size="100%">Nucleic Acid Denaturation</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyethylene Glycols/chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyridinium Compounds/*chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Solvents/chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Telomere/*chemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Sep 1</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/22735707</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">17</style></number><volume><style face="normal" font="default" size="100%">40</style></volume><pages><style face="normal" font="default" size="100%">8711-20</style></pages><isbn><style face="normal" font="default" size="100%">1362-4962 (Electronic)0305-1048 (Linking)</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Because various non-parallel G-quadruplexes of human telomeric sequences in K+ solution can be converted to a parallel G-quadruplex by adding polyethylene glycol (PEG) as a co-solvent, we have taken advantage of this property of PEG to study the covalent attachment of a PEG unit to a G-quadruplex ligand, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC). The hybrid ligand with the PEG unit, BMVC-8C3O or BMVC-6C2O by substituting either the tetraethylene glycol or the triethylene glycol terminated with a methyl-piperidinium cation in N-9 position of BMVC, not only induces structural change from different non-parallel G-quadruplexes to a parallel G-quadruplex but also increases the melting temperature of human telomeres in K+ solution by more than 45 degrees C. In addition, our ligand work provides further confidence that the local water structure plays the key to induce conformational change of human telomere.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">22735707</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;Wang, Zi-FuChang, Ta-ChauengResearch Support, Non-U.S. Gov'tEngland2012/06/28 06:00Nucleic Acids Res. 2012 Sep 1;40(17):8711-20. Epub 2012 Jun 26.&lt;/p&gt;
</style></notes><custom2><style face="normal" font="default" size="100%">3458535</style></custom2><auth-address><style face="normal" font="default" size="100%">Department of Chemistry, National Taiwan University, Academia Sinica, Taipei 106, Taiwan, ROC.</style></auth-address></record></records></xml>