<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chou, Y. S.</style></author><author><style face="normal" font="default" size="100%">Chang, C. C.</style></author><author><style face="normal" font="default" size="100%">Chang, T. C.</style></author><author><style face="normal" font="default" size="100%">Yang, T. L.</style></author><author><style face="normal" font="default" size="100%">Young, T. H.</style></author><author><style face="normal" font="default" size="100%">Lou, P. J.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Photo-Induced Antitumor Effect of 3,6-Bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide</style></title><secondary-title><style face="normal" font="default" size="100%">Biomed Research International</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Biomed Res Int</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bmvc</style></keyword><keyword><style  face="normal" font="default" size="100%">cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">cells</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">light</style></keyword><keyword><style  face="normal" font="default" size="100%">photodynamic therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">photosensitizer</style></keyword><keyword><style  face="normal" font="default" size="100%">quadruplex structure</style></keyword><keyword><style  face="normal" font="default" size="100%">telomerase</style></keyword><keyword><style  face="normal" font="default" size="100%">tumors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/23509809</style></url></web-urls></urls><isbn><style face="normal" font="default" size="100%">2314-6133</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We have applied a fluorescent molecule 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC) for tumor targeting and treatment. In this study, we investigated the photo-induced antitumor effect of BMVC. In vitro cell line studies showed that BMVC significantly killed TC-1 tumor cells at light dose greater than 40 J/cm(2). The fluorescence of BMVC in the tumor peaked at 3 hours and then gradually decreased to reach the control level a. er 24 hours. In vivo tumor treatment studies showed BMVC plus light irradiation (iPDT) significantly inhibited the tumor growth. At day 24 a. er tumor implantation, tumor volume was measured to be 225 +/- 79 mm(3), 2542 +/- 181 mm(3), 1533 +/- 766 mm(3), and 1317 +/- 108 mm(3) in the iPDT, control, light-only, and BMVC-only groups, respectively. Immunohistochemistry studies showed the microvascular density was significantly lower in the iPDT group. Taken together, our results demonstrated that BMVC may be a potent tumor-specific photosensitizer (PS) for PDT.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000314957000001</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;090CRTimes Cited:0Cited References Count:32&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Lou, PJNatl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 10002, TaiwanNatl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 10002, TaiwanNatl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10002, TaiwanNatl Taiwan Univ, Coll Engn, Taipei 10002, TaiwanNatl Chung Hsing Univ, Grad Inst Biomed Engn, Taichung 40254, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, Taipei 10617, TaiwanNatl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 10002, TaiwanColl Med, Taipei 10002, Taiwan</style></auth-address></record></records></xml>