<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wei, P. C.</style></author><author><style face="normal" font="default" size="100%">Wang, Z. F.</style></author><author><style face="normal" font="default" size="100%">Lo, W. T.</style></author><author><style face="normal" font="default" size="100%">Su, M. I.</style></author><author><style face="normal" font="default" size="100%">Shew, J. Y.</style></author><author><style face="normal" font="default" size="100%">Chang, T. C.</style></author><author><style face="normal" font="default" size="100%">Lee, W. H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress</style></title><secondary-title><style face="normal" font="default" size="100%">Nucleic Acids Research</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nucleic Acids Res</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">c-myc</style></keyword><keyword><style  face="normal" font="default" size="100%">complex-formation</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA structures</style></keyword><keyword><style  face="normal" font="default" size="100%">gene</style></keyword><keyword><style  face="normal" font="default" size="100%">initiation</style></keyword><keyword><style  face="normal" font="default" size="100%">myc g-quadruplex</style></keyword><keyword><style  face="normal" font="default" size="100%">protein</style></keyword><keyword><style  face="normal" font="default" size="100%">region</style></keyword><keyword><style  face="normal" font="default" size="100%">telomeric DNA</style></keyword><keyword><style  face="normal" font="default" size="100%">transcription</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Feb</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/23241391</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">3</style></number><volume><style face="normal" font="default" size="100%">41</style></volume><pages><style face="normal" font="default" size="100%">1533-1543</style></pages><isbn><style face="normal" font="default" size="100%">0305-1048</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We reported that non-targeting siRNA (NT-siRNA) stress induces non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) expression to cooperate with exoribonuclease XRN2 for releasing the stress [Wei,P.C., Lo,W.T., Su,M.I., Shew,J.Y. and Lee, W. H. (2011) Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress. Nucleic Acids Res., 40, 323-332]. However, how NT-siRNA stress inducing NPGPx expression remains elusive. In this communication, we showed that the proximal promoter of NPGPx contained a mixed G-quadruplex (G4) structure, and disrupting the structure diminished NT-siRNA induced NPGPx promoter activity. We also demonstrated that nucleolin (NCL) specifically bonded to the G4-containing sequences to replace the originally bound Sp1 at the NPGPx promoter on NT-siRNA stress. Consistently, overexpression of NCL further increased NPGPx promoter activity, whereas depletion of NCL desensitized NPGPx promoter to NT-siRNA stress. These results suggest that the cis-element with mixed G4 structure at the NPGPx promoter plays an essential role for its transactivation mediated by NCL to release cells from NT-siRNA stress.&lt;/p&gt;
</style></abstract><accession-num><style face="normal" font="default" size="100%">WOS:000316351800021</style></accession-num><notes><style face="normal" font="default" size="100%">&lt;p&gt;109FMTimes Cited:0Cited References Count:33&lt;/p&gt;
</style></notes><auth-address><style face="normal" font="default" size="100%">Lee, WHGenom Res Ctr, Taipei 11529, TaiwanGenom Res Ctr, Taipei 11529, TaiwanNatl Def Med Ctr, Grad Inst Life Sci, Taipei 11490, TaiwanGenom Res Ctr, Taipei 11529, TaiwanAcad Sinica, Inst Atom &amp; Mol Sci, Taipei 11529, TaiwanNatl Taiwan Univ, Dept Chem, Taipei 11529, TaiwanAcad Sinica, Inst Biol Chem, Taipei 11529, TaiwanUniv Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA</style></auth-address></record></records></xml>