@article {570,
	title = {Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol},
	journal = {Nucleic Acids Res},
	volume = {40},
	number = {17},
	year = {2012},
	note = {<p>Wang, Zi-FuChang, Ta-ChauengResearch Support, Non-U.S. Gov{\textquoteright}tEngland2012/06/28 06:00Nucleic Acids Res. 2012 Sep 1;40(17):8711-20. Epub 2012 Jun 26.</p>
},
	month = {Sep 1},
	pages = {8711-20},
	abstract = {<p>Because various non-parallel G-quadruplexes of human telomeric sequences in K+ solution can be converted to a parallel G-quadruplex by adding polyethylene glycol (PEG) as a co-solvent, we have taken advantage of this property of PEG to study the covalent attachment of a PEG unit to a G-quadruplex ligand, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC). The hybrid ligand with the PEG unit, BMVC-8C3O or BMVC-6C2O by substituting either the tetraethylene glycol or the triethylene glycol terminated with a methyl-piperidinium cation in N-9 position of BMVC, not only induces structural change from different non-parallel G-quadruplexes to a parallel G-quadruplex but also increases the melting temperature of human telomeres in K+ solution by more than 45 degrees C. In addition, our ligand work provides further confidence that the local water structure plays the key to induce conformational change of human telomere.</p>
},
	keywords = {*G-Quadruplexes, Carbazoles/*chemistry, Circular Dichroism, Ligands, Nucleic Acid Denaturation, Polyethylene Glycols/chemistry, Pyridinium Compounds/*chemistry, Solvents/chemistry, Telomere/*chemistry},
	isbn = {1362-4962 (Electronic)0305-1048 (Linking)},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/22735707},
	author = {Wang, Z. F. and Chang, T. C.}
}
