Ta-Chau Chang

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Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe

Citation:
TL, Y, L L, PJ L, TC C, TH Y.  2014.  Detection of cell carcinogenic transformation by a quadruplex DNA binding fluorescent probe. PloS one. 9(1):e86143.
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Recent Publications

  • Expression of the human telomerase reverse transcriptase gene is modulated by quadruplex formation in its first exon due to DNA methylation
  • A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes.
  • Specific polyunsaturated fatty acids modulate lipid delivery and oocyte development in C. elegans revealed by molecular-selective label-free imaging.
  • A Fluorescent Anti-Cancer Agent, 3,6-bis(1-methyl-4-vinylpyridinium) Carbazole Diiodide, Stains G-Quadruplexes in Cells and Inhibits Tumor Growth
  • Conformational transition of a hairpin structure to G-quadruplex within the WNT1 gene promoter
  • Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
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