@article {Dhenadhayalan2018929,
	title = {Aptamer-based fluorogenic sensing of interferon-gamma probed with ReS2 and TiS2 nanosheets},
	journal = {Sensors and Actuators, B: Chemical},
	volume = {258},
	year = {2018},
	note = {<p>cited By 0</p>
},
	pages = {929-936},
	abstract = {<p>The fluorogenic aptamer sensing of interferon-gamma (IFN-γ) was scrutinized using two-dimensional (2D) ReS2 and TiS2 nanosheets (NSs) as a platform. The IFN-γ an important cytokine, functions as a bio-indicator to detect infectious diseases such as tuberculosis and human immunodeficiency virus. This 2D NSs based aptamer sensor was implemented to induce the fluorescence off/on resulting from an aptamer, in the absence or presence of a target to be probed. The fluorescence emitting from the aptamer is quenched by interacting with NSs, while the ensuing fluorescence is recovered upon addition of target. Such a fluorescence off/on mechanism was proposed based on the behavior of fluorescence resonance energy transfer (FRET) between the aptamer and NSs. The fluorescence response exhibits linearity as a function of target, and the detection limit of IFN-γ was evaluated to be 57.6 and 82.7 pM for ReS2 and TiS2 NSs, respectively, being comparable to or even better than those methods adopted for probing IFN-γ. The selectivity property was also characterized with various targets, exhibiting a very specific selectivity for IFN-γ. The findings reveal that the aptamer-transition metal dichalcogenides (TMD) NSs will be a great sensing pair to the development of aptamer-based biosensors. Moreover, the biocompatibility and sensing capability of IFN-γ was implemented in human embryonic kidney 293T (HEK) live cells. This is the first report to emerging fluorogenic sensing of IFN-γ aptamer with 2D TMD, showing a promising trend for future design of biosensors. {\textcopyright} 2017 Elsevier B.V.</p>
},
	keywords = {Antibiotics, Aptamers, Biocompatibility, Biosensors, Diseases, Energy transfer, Fluorescence, Fluorescence Resonance Energy Transfer, Glycoproteins, Human embryonic kidneys, Human immunodeficiency virus, Interferon-gamma, NANOSHEETS, Rhenium compounds, Specific selectivity, Titanium compounds, Transition metal dichalcogenides (TMD), Transition metals, Two Dimensional (2 D), Viruses},
	doi = {10.1016/j.snb.2017.11.178},
	url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85036647797\&doi=10.1016\%2fj.snb.2017.11.178\&partnerID=40\&md5=d46150b3d1fe9172a9607b8856b334ae},
	author = {Dhenadhayalan, N. and Sriram, M.I. and Lin, K.-C.}
}
